Tony Arulanandam

Company: Synaptimmune Therapeutics

Job title: CEO and Founder

Seminars:

TCR like Condensate Signaling in Intrinsically Disordered Regions Forms Microsynapses & Shows Increased Potency Against Solid Tumors and is Amenable to Combination Therapy With ICIs and mRNA CAR Antigen Vaccines 5:00 pm

• IDR domains in CAR receptors induce phase separation and TCR like condensate formation, signaling and microsynapse formation • Microsynapse formation is expected to increase PD-1 and CD28 in the immune synapse and hence sensitize to PD-1 checkpoint blockade • mRNA CAR antigen vaccines can actívate and expand IDR-CAR-T cells to show increased persistence. Tumor…Read more

day: Day One