Deb Kientop

Company: DEKA Biosciences

Job title: Vice President, Clinical Operations

Seminars:

Clinical update on DK210 (EGFR): Reducing Toxicity & Enhancing Potency of Cytokine Therapy through Rational Combination Strategies 12:30 pm

• Coupling IL-10 with IL-2 reduces IL-2 toxicity by attenuating the induction of cytokine release syndrome • Coupling IL-10 with IL-2 uncouples toxicity from T and NK cell activation, reducing risk of vascular/capillary leak syndrome • Targeting to the surface of tumor cells enhances anti-tumor potency in vivo through its independent accumulation in the T…Read more

day: Day Two