TCR like Condensate Signaling in Intrinsically Disordered Regions Forms Microsynapses & Shows Increased Potency Against Solid Tumors and is Amenable to Combination Therapy With ICIs and mRNA CAR Antigen Vaccines
Time: 5:00 pm
day: Day One
Details:
• IDR domains in CAR receptors induce phase separation and TCR like condensate formation, signaling and microsynapse formation
• Microsynapse formation is expected to increase PD-1 and CD28 in the immune synapse and hence sensitize to PD-1 checkpoint blockade
• mRNA CAR antigen vaccines can actívate and expand IDR-CAR-T cells to show increased persistence. Tumor killing by IDR-CAR-T cells can increase antigen presentation and activation of endogenous immunity
