Clinical update on DK210 (EGFR): Reducing Toxicity & Enhancing Potency of Cytokine Therapy through Rational Combination Strategies
Time: 12:30 pm
day: Day Two
Details:
• Coupling IL-10 with IL-2 reduces IL-2 toxicity by attenuating the induction of cytokine release syndrome
• Coupling IL-10 with IL-2 uncouples toxicity from T and NK cell activation, reducing risk of vascular/capillary leak syndrome
• Targeting to the surface of tumor cells enhances anti-tumor potency in vivo through its independent accumulation in the T cell synapse, enhancing T cell recognition and cytolytic function
